Nicaraguans are living under an increasingly anti-democratic regime that has deepened the crisis by actions and inactions against the communal and individual rights of the indigenous and Afro-descendant population in Nicaragua. Political violence, elimination of autonomy on the Caribbean Coast and armed violence committed by third parties backed by national authorities have caused an exodus and possible genocide of indigenous communities, particularly of the Nicaraguan Muskitia people. In confronting this situation, communities, social organizations and the Observatory of Indigenous Peoples have developed a strategy of territorial structuring for the joint care of life and common property, a strategy that seeks the regionalization of indigenous resistance.